Product details
Neutrophil Gelatinase-Associated Lipocalin (NGAL) Test Kit (Fluorescence Immunoassay)
Application
It is suitable for quantitative determination of neutrophil gelatinase-related lipocalin (NGAL) in human plasma or whole blood in vitro.
Package
1 test/kit, 5 tests/kit, 10 tests/kit, 25 tests/kit, 50 tests/kit.
Glossary
Lipid metabolism disorders are closely related to the occurrence and development of cardiovascular and cerebrovascular diseases. In recent years, lipid metabolism in patients with diabetes and hypertension has been detected by lipidomics, and lipid markers of diseases have been explored to assist clinical diagnosis and treatment. Disease prevention.
Common plasma lipid markers, such as tumor necrosis factor-α (TNF-α), adipocyte-type fatty acid-binding protein (A-FABP), interleukin-6 (IL-6), and resistin, promote inflammation; An important adipokine, adiponectin, plays an anti-inflammatory role. These adipokines play an important bridge role in the occurrence and development of obesity and metabolic diseases.
Clinical Significance
1. Early diagnosis and prevention of acute kidney injury (AKI)
2. Risk stratification and prognostic assessment of acute kidney injury (AKI)
3. Early diagnosis of contrast-associated nephropathy (CIN)
4. Post-rain assessment of renal injury complicated by kidney transplantation
5. Diagnosis and prognosis of cardiorenal syndrome
6. Early diagnosis of diabetic nephropathy
Long-term monitoring of critically ill patients in ICU
Main components
The kit consists of neutrophil gelatinase-related lipocalin detection reagent card, detection buffer, ID card, and instructions.
Neutrophil gelatinase-related lipocalin detection reagent card: neutrophil gelatinase-related lipocalin monoclonal antibody (0.1-2 mg/mL), anti-chicken IgY polyclonal antibody (0.1-2 mg/mL) , time-resolved fluorescent microsphere-labeled neutrophil gelatinase-related lipocalin monoclonal antibody (0.1-2 mg/mL) and time-resolved fluorescent microsphere-labeled chicken IgY antibody (0.1-2 mg/mL).
Detection buffer: 0.01M phosphate buffer, pH=7.4±0.5, Proclin 300 0.3g/L.
Packaging:
1. one piece in one carry bag
2. Suitable quantity to an export carton
3. No other packing accessories in regular
4. Customer required packing is available
Neutrophil gelatinase-associated lipocalin (NGAL)
Neutrophil gelatinase-associated lipocalin (NGAL), a type of lipocalin, was originally a small molecular weight secreted protein found in activated neutrophils. Modern studies have shown that NGAL is a diagnostic tool for acute kidney injury. It is one of the most effective biological markers of diabetes and one of the effective markers of early diabetic nephropathy.
NGAL is anti-inflammatory and anti-inflammatory, can promote the differentiation of renal progenitor cells into early renal tubular epithelial cells, can repair N-cadherin, upregulate the protective enzyme heme oxygenase and inhibit cell death. NGAL has powerful functions. In addition to the function of binding and transporting hydrophobic small molecules as a member of the lipid family, NGAL is also involved in inflammation, embryonic development, immune response, chemotaxis, signal transduction, and the occurrence and development of various tumors. related.
Acute kidney injury (AKI) is a common and serious complication in hospitalized patients with severe morbidity and mortality. In clinical practice, serum creatinine level and urine output are the most commonly used indicators of renal dysfunction, but they have certain limitations. First, they did not distinguish between purely functional hemodynamic triggers of structural kidney injury and reduced GFR. Second, delays in diagnosis lead to accumulation of creatinine, which inevitably delays treatment. Due to the delayed response to creatinine and the lack of specific symptoms, AKI may be at an advanced stage at the time of diagnosis, and early specific treatment for endogenous acute kidney injury is often unavailable. On the other hand, creatinine usually reflects chronic kidney disease rather than acute kidney injury. They have limited sensitivity and specificity and slow changes in creatinine levels, thus limiting their application in the early detection of AKI.
Three markers of neutrophil gelatinase-associated lipocalin (NGAL):
1. Early markers of acute kidney disease
2. Early markers of chronic kidney disease
3. Early markers of diabetic nephropathy
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